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Decrease in KCl-stimulated insulin secretion induced by exposure to extremely low frequency magnetic fields
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Tomonori Sakurai, Shin Koyama, Yoshiki Komatsubara, Wang Jin, Junji Miyakoshi,
03/11/2005
Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Hirosaki University, Hirosaki, Japan
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Abstract:
We previously reported that exposure to an extremely low frequency magnetic field (ELFMF) attenuated potassium chloride (KCl)-stimulated insulin secretion.
In this study, we evaluated the conditions under which KCl-stimulated insulin secretion was influenced by exposure to ELFMF and investigated the mechanisms of the effects of ELFMF on KCl-stimulated insulin secretion. The effects of ELFMF on KCl-stimulated insulin secretion were tested under conditions of differing magnetic flux densities and concentrations of KCl. KCl-stimulated insulin secretion was attenuated by exposure to ELFMF at 5 mT in the presence of 45 mM KCl. Under these conditions, the decrease in the degree of depolarization by ELFMF was observed with flow cytometry. ELFMF exposure did not influence (S)-(-)-Bay K8644-induced insulin secretion.
In conclusion, we demonstrated that the decrease in insulin secretion induced by ELFMF was only detected at high magnetic flux density and in the presence of a high concentration KCl. The effects of ELFMF continued during the KCl-stimulated insulin secretion and the decrease in the degree of depolarization is closely associated with the ELFMF-induced attenuation of insulin secretion.
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Keywords:
Diabetes, ELF magnetic field, depolarization, RIN-m cells
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